Trials available to date have not assessed the safety of ranitidine in uncomplicated duodenal ulcer for periods of more than 8 weeks.
Like other drugs ranitidine should only be used during breast-feeding if considered essential.
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Ranitidine is a competitive inhibitor of histamine at histamine h2-receptor sites.
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When omeprazole and ranitidine were compared in a study of 144 people with severe inflammation and erosions or ulcers of the esophagus, 85 of those treated with omeprazole healed within eight weeks, compared to 50 of those given ranitidine.
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